Programmed death-1 (PD-1)是在T細(xì)胞上表達(dá)的抑制性受體，它能促進(jìn)炎性T細(xì)胞的凋亡并抑制抗炎調(diào)節(jié)性T細(xì)胞的凋亡，從而提高自身耐受性并預(yù)防自身免疫性疾病。為了逃避免疫監(jiān)視，腫瘤細(xì)胞經(jīng)常通過過度表達(dá)PD-L1來利用這一系統(tǒng)，PD-L1是一種結(jié)合并激活PD-1的配體。抗PD-1單克隆抗體用于阻斷PD-L1與PD-1的結(jié)合，從而使免疫系統(tǒng)能夠發(fā)現(xiàn)并殺死腫瘤細(xì)胞。

產(chǎn)品名稱:InVivoMab anti-mouse PD-1 (CD279)抗體

反應(yīng)種屬:mouse

宿主來源:rat

實驗應(yīng)用:in vivo blocking of PD-1/PD-L signaling

同種型:IgG2a, κ

免疫原:Syrian Hamster BKH cells transfected with mouse PD-1 cDNA

克隆性:Monoclonal

克隆號:RMP1-14

產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

保存溫度:Undiluted at 4°C in the dark

運輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

預(yù)期分子量:150 kDa

產(chǎn)品形式:液體

有效期:One year from the date of receipt if stored as recommended

產(chǎn)地:美國

InVivoMab anti-mouse PD-1 (CD279)抗體

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